On Monday Night Football, Estadio Azteca will play host

to the fourth-ever NFL game in Mexico. The San Francisco 49ers and

Arizona Cardinals will play each other in a rematch of the first NFL game ever

played outside of the United States, which the Cardinals won in Mexico City in 2005.

Arizona defeated San Francisco in both meetings during the 2021 season

but the Cardinals are only 4-6 to start the 2022 season. After two victories

the 49ers have an overall record of 5-4. Kyler Murray,

 the quarterback for the Cardinals, is out due to a hamstring issue.